https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30607 Eucalyptus species using an MTT assay. The most promising extracts were further evaluated using a CCK-8 assay. Apoptotic studies were performed using a caspase 3/7 assay in MIA PaCa-2 cells. The aqueous extract of Eucalyptus microcorys leaf and the ethanolic extract of Eucalyptus microcorys fruit inhibited the growth of glioblastoma, neuroblastoma, lung and pancreatic cancer cells by more than 80% at 100 μg/mL. The E. microcorys and Eucalyptus saligna extracts showed lower GI₅₀ values than the ethanolic Eucalyptus robusta extract in MIA PaCa-2 cells. Aqueous E. microcorys leaf and fruit extracts at 100 μg/mL exerted significantly higher cell growth inhibition in MIA PaCa-2 cells than other extracts (p < 0.05). Statistically similar IC₅₀ values (p > 0.05) were observed in aqueous E. microcorys leaf (86.05 ± 4.75 μg/mL) and fruit (64.66 ± 15.97 μg/mL) and ethanolic E. microcorys leaf (79.30 ± 29.45 μg/mL) extracts in MIA PaCa-2 cells using the CCK-8 assay. Caspase 3/7-mediated apoptosis and morphological changes of cells were also witnessed in MIA PaCa-2 cells after 24 h of treatment with the extracts. This study highlighted the significance of E. microcorys as an important source of phytochemicals with efficacy against pancreatic cancer cells. Further studies are warranted to purify and structurally identify individual compounds and elucidate their mechanisms of action for the development of more potent and specific chemotherapeutic agents for pancreatic cancer.]]> Wed 19 Jan 2022 15:15:45 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37096 Wed 17 Nov 2021 16:30:40 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44237 Artemisia vulgaris is a traditional Chinese herb believed to have a wide range of healing properties; it is traditionally used to treat numerous health ailments. The plant is commonly called mugwort or riverside wormwood. The plant is edible, and in addition to its medicinal properties, it is also used as a culinary herb in Asian cooking in the form of a vegetable or in soup. The plant has garnered the attention of researchers in the past few decades, and several research studies have investigated its biological effects, including antioxidant, anti-inflammatory, anticancer, hypolipidemic, and antimicrobial properties. In this review, various studies on these biological effects are discussed along with the tests conducted, compounds involved, and proposed mechanisms of action. This review will be of interest to the researchers working in the field of herbal medicine, pharmacology, medical sciences, and immunology.]]> Tue 11 Oct 2022 12:13:02 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34442 Tue 03 Sep 2019 18:00:55 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36359 Thu 28 Oct 2021 13:03:11 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50836 Thu 17 Aug 2023 11:57:21 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38357 Thu 09 Sep 2021 12:21:31 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30611 Corymbia and Angophora. Four Angophora and Corymbia species were evaluated for their phytochemical profile and efficacy against both primary and secondary pancreatic cancer cell lines. The aqueous leaf extract of Angophora hispida exhibited statistically higher total phenolic content (107.85 ± 1.46 mg of gallic acid equiv. per g) and total flavonoid content (57.96 ± 1.93 mg rutin equiv. per g) and antioxidant capacity compared to the other tested eucalypts (P < 0.05). Both A. hispida and A. floribunda aqueous extracts showed statistically similar saponin contents. Angophora floribunda extract exerted significantly greater cell growth inhibition of 77.91 ± 4.93% followed by A. hispida with 62.04 ± 7.47% (P < 0.05) at 100 μg/ml in MIA PaCa-2 cells with IC₅₀ values of 75.58 and 87.28 μg/ml, respectively. More studies are required to isolate and identify the bioactive compounds from these two Angophora species and to determine their mode of action against pancreatic malignancies.]]> Thu 09 Dec 2021 11:03:07 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9676 Sat 24 Mar 2018 08:39:16 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:8093 Sat 24 Mar 2018 08:34:28 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18380 Sat 24 Mar 2018 07:52:42 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:3264 Sat 24 Mar 2018 07:21:22 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32711 Fri 20 Sep 2019 02:27:30 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41789 Fri 12 Aug 2022 12:17:33 AEST ]]>